Long intergenic non-protein coding RNA 173 (LINC00173)

Long intergenic non-protein coding RNA 173 (LINC00173) is a long non-coding RNA (lncRNA) located on human chromosome 12 and does not encode a protein[2][5][7]. It regulates gene expression primarily by acting as a competing endogenous RNA, sponging specific microRNAs such as miR-765, miR-490-3p, and miR-218[4]. LINC00173 is implicated in the regulation of cell proliferation, migration, invasion, and apoptosis and is strongly associated with various human cancers[1][4][8]. Its aberrant expression influences tumor progression and patient prognosis; high expression levels are generally linked to increased tumor aggressiveness and poor clinical outcomes in cancers like glioma, melanoma, and nasopharyngeal carcinoma[1][4][8][9]. Despite multiple studies on its relevance as a diagnostic, prognostic, and potential therapeutic target, there are no direct drugs known to interact with or target LINC00173 as of now[5]. While most studies highlight its oncogenic properties, some evidence suggests a suppressive role in certain contexts, highlighting the complexity of its functional impact on disease[6].

Other names

NCRNA00173FLJ42957Putative uncharacterized protein encoded by LINC00173

Modulation of gene expression via miRNA sponging (e.g., miR-765, miR-490-3p, miR-218)