Long intergenic non-protein coding RNA 173 (LINC00173) (LINC00173)

Long intergenic non-protein coding RNA 173 (LINC00173) is a long non-coding RNA transcript (~543 nucleotides, chromosome 12q24.22), with no known protein-coding capacity[1]. It has several transcript variants and is found in both nuclear and cytoplasmic compartments, influencing gene expression at both the transcriptional and post-transcriptional levels. LINC00173 is aberrantly expressed in at least eleven human cancers, where it often functions as a competitive endogenous RNA (“ceRNA” or miRNA sponge), thereby regulating downstream target genes involved in cell proliferation, migration, invasion, apoptosis, and resistance to chemotherapy. Its dysregulation has been implicated in cancer development, progression, and chemoresistance, making it a novel candidate biomarker and a potential therapeutic target, although it is not a receptor, enzyme, or conventional drug target[1][3].

Other names

NCRNA00173LINC00173

Regulation of downstream gene expression through miRNA “sponging” (e.g., binds miR-765, miR-218, miR-182-5p, miR-641, miR-338-3p, etc.) Modulates chemoresistance mechanisms and influences cell fate via regulation of oncogenes and tumor suppressors downstream of these miRNAs (e.g., PLP2, Etk, NUTF2, VEGFA, RAB14, Rab25, FBXW7, AGER/NF-κB pathway, SPHK1, MGAT1)