Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Long intergenic non-protein coding RNA 1816 (LINC01816)
- Target
- LINC01816
- Molecular classification
- Long non-coding RNA (lncRNA), Intergenic non-coding RNA
01
Overview
LINC01816 is a long intergenic non-protein coding RNA (lncRNA) implicated primarily in gene regulation through microRNA (miRNA) interactions, often acting as a "sponge" for specific miRNAs such as miR-34c-5p. In thyroid carcinoma, its overexpression promotes migration, invasion, and epithelial-mesenchymal transition (EMT) by modulating the miR-34c-5p/CRABP2 axis. Upregulation of LINC01816 has been associated with poor prognosis in several cancers. Although it is not classified as a traditional pharmacological target like a receptor or enzyme, LINC01816 is proposed as a potential novel biomarker and may become a focus for RNA-based therapeutic strategies in oncology[1][3][5][6].
- Other names
- LINC01816LOC100133985long intergenic non-protein coding RNA 1816
02
Biological functions
Regulation of gene expression via competing endogenous RNA (ceRNA) mechanismsPromotion of epithelial-mesenchymal transition (EMT)Facilitation of cell migration and invasion in cancer cellsModulation of cell cycle (G2/M arrest in some contexts)
03
Disease associations
Cancer (notably thyroid carcinoma and possibly other types such as colorectal and esophageal squamous cell carcinoma)
04
Biomarkers
LINC01816 expression may serve as a biomarker for cancer progression or prognosis, especially in thyroid carcinoma
Beyond the preview
Go deeper on Long intergenic non-protein coding RNA 1816 (LINC01816).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Long intergenic non-protein coding RNA 1816 (LINC01816).