Target intelligence / Profile preview

Long intergenic non-protein coding RNA 1845 (LINC01845)

Target
LINC01845
Molecular classification
Long non-coding RNA (lncRNA), Long intergenic non-coding RNA (lincRNA)
01

Overview

Long intergenic non-protein coding RNA 1845 (LINC01845) is a human long intergenic non-coding RNA (lincRNA) gene that transcribes a non-protein-coding RNA molecule[1][5]. LincRNAs are a subclass of long non-coding RNAs situated between protein-coding genes, typically lacking protein-coding potential but playing regulatory roles in gene expression[3]. LINC01845 has been identified through bioinformatic and machine learning analyses as one of several lncRNAs with significant differential expression in lung cancer, suggesting utility as a diagnostic biomarker in distinguishing lung cancer tissue from normal tissue[2]. However, there are no reports of LINC01845 acting as a direct therapeutic target (e.g., a receptor, enzyme, transporter), nor are there any known drugs or therapies that directly interact with it, nor associations with molecular mechanisms of action or safety considerations. Its main relevance currently appears as a candidate biomarker in oncology[2].

Other names
LINC01845
02

Biological functions

Regulation of gene expression (inferred general function of lincRNAs[3])Potential roles in cancer biology as a biomarker[2]
03

Disease associations

Cancer (specifically noted roles as a biomarker in non-small cell lung cancer and possibly other tumors[2])
04

Biomarkers

Diagnostic biomarker for lung cancer, as part of a gene signature distinguishing tumor from normal tissue[2]

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