Long intergenic non-protein coding RNA 1913 (LINC01913)

Long intergenic non-protein coding RNA 1913 (LINC01913) is a non-protein-coding intergenic transcript, part of the long non-coding RNA family, expressed from chromosome 2p21. Recent clinical research identifies LINC01913 as a novel lncRNA with oncogenic properties, correlating its overexpression in gastric cancer tumors to lymph node metastasis, deeper tumor invasion, and poorer overall survival in affected patients. Functional evidence links LINC01913's regulatory roles to the PI3K-AKT and EMT pathways, which are critical in cancer cell proliferation and metastasis. Although LINC01913 is not a traditional therapeutic target, research highlights its potential value as a clinical biomarker for diagnosis and prognosis in gastro-intestinal malignancies, subject to ongoing validation in multicenter studies.

Other names

LINC01913

Not applicable; current data do not indicate a direct mechanism for drug action against LINC01913, though its regulation may intersect PI3K-AKT and EMT pathways, suggesting possible indirect modulation as understanding evolves.