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Long intergenic non-protein coding RNA 1923 (LINC01923)
- Target
- LINC01923
- Molecular classification
- Long non-coding RNA (lncRNA), Non-protein coding gene, Intergenic RNA
01
Overview
Long intergenic non-protein coding RNA 1923 (LINC01923) is a human long non-coding RNA gene located in genomic regions that do not overlap with any protein-coding genes. Like other lincRNAs, LINC01923 may be involved in regulating gene expression and local chromatin architecture, particularly in brain cell types, as suggested by recent single-cell epigenomic studies. A prominent chromatin loop connects the promoter of SATB2, an excitatory neuron marker, to the LINC01923 locus, suggesting cell-type-specific genomic architecture in the human cortex[2]. However, its precise biological functions, involvement in disease, and potential as a therapeutic target remain uncharacterized. There are no known drugs, biomarkers, or clinical safety issues directly associated with LINC01923[1][2][3].
- Other names
- LINC01923long intergenic non-protein coding RNA 1923
02
Biological functions
Chromatin architecture: Recent single-cell multi-omics studies indicate that the LINC01923 genomic locus may participate in higher-order chromatin loop formation with neuronal marker genes such as SATB2, which is specific to excitatory neurons in the cerebral cortexLikely involved in gene regulation at the epigenetic and transcriptomic level, as is typical for long intergenic non-coding RNAs (lincRNAs), but its specific regulatory role in human biology is not well characterized
03
Disease associations
There is no direct, validated association of LINC01923 with specific human diseases in current databases or literatureLINC01923 was discussed in the context of chromatin loops relevant to neuron classification; indirect implication in neurobiology is plausible, but evidence of pathogenic or therapeutic roles remains insufficientNo confirmed links to cancer, inflammation, neurodegenerative disease, cardiovascular disease, infection, or other disease categories
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