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Long intergenic non-protein coding RNA 1936 (LINC01936)
- Target
- LINC01936
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
Long intergenic non-protein coding RNA 1936 (LINC01936) is a long non-coding RNA located at chromosome 2p23.1, primarily expressed in the lung, heart, and thyroid[1][2][5]. It is significantly downregulated in lung squamous cell carcinoma (LUSC) and lung adenocarcinoma, where it functions as a tumor suppressor. Overexpression of LINC01936 reduces proliferation, migration, and invasion of LUSC cells while promoting apoptosis. Mechanistically, LINC01936 is involved in deactivation of epithelial-mesenchymal transition (EMT), regulation of immune cell infiltration, inhibition of angiogenesis, and modulation of cell adhesion and extracellular matrix-interactions. Its lower expression correlates with worse prognosis in lung cancer, making it a potential prognostic biomarker and a putative therapeutic target for lung cancers. Currently, there are no known drugs or direct targeting modalities for LINC01936, and its therapeutic application remains investigational[1][2][3][5].
- Other names
- NONHSAG0273390.2HSALNG0013967NR_122048.1
02
Biological functions
Regulation of cell proliferationRegulation of cell migrationRegulation of cell invasionPromotion of apoptosisRegulation of epithelial-mesenchymal transition (EMT)Modulation of immune cell infiltrationRegulation of extracellular matrix interactionRegulation of endothelial cell proliferationRegulation of angiogenesis
03
Disease associations
CancerLung squamous cell carcinoma (LUSC)Lung adenocarcinoma (prognostic marker)Other (potential tumor suppressor)
04
Biomarkers
Prognostic marker for lung adenocarcinomaPrognostic marker for lung squamous cell carcinoma
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