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Long intergenic non-protein coding RNA 1943 (LINC01943)
- Target
- LINC01943
- Molecular classification
- Long intergenic non-coding RNA (lincRNA), Non-coding RNA, Other
01
Overview
Long intergenic non-protein coding RNA 1943 (LINC01943) is a member of the long intergenic non-coding RNA (lincRNA) family, transcribed as a non-coding RNA greater than 200 nucleotides and does not overlap with protein-coding loci[1][5][3]. LINC01943 has been identified as part of prognostic models for melanoma, where its elevated expression is a protective factor associated with improved overall survival[2]. It also marks regulatory T cells within the PDAC tumor microenvironment, suggesting involvement in immune modulation within cancers[6]. While the detailed molecular function of LINC01943 itself remains unexplored and its gene regulatory mechanisms are not defined, its inclusion in cancer prognostic panels and cell-type specificity add to its emerging relevance in cancer biology. There are currently no drugs known to directly target LINC01943, and its role is limited to non-coding RNA-based biomarker or prognostic applications.
- Other names
- LINC01943long intergenic non-protein coding RNA 1943
02
Biological functions
Gene regulation (putative, based on lincRNA class)Regulation of autophagy-related processes (prognostic relevance in melanoma suggested but specific molecular roles unconfirmed)Regulation of immune cell function (specifically in regulatory T cells in PDAC microenvironment)Other
03
Disease associations
CancerPrognostic biomarker in melanomaDifferentially expressed in pancreatic ductal adenocarcinoma (association with regulatory T cells in tumor microenvironment)Other
04
Biomarkers
Prognostic marker for survival and risk stratification in melanoma (based on a 15-lncRNA autophagy-related risk model)Cell-type marker for regulatory T cells in PDAC tumor microenvironment
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