Long intergenic non-protein coding RNA 1960 (LINC01960)

Long intergenic non-protein coding RNA 1960 (LINC01960) is a non-coding RNA molecule that has been identified as playing a notable role in the regulation of decidualization of endometrial stromal cells, particularly in the context of endometriosis and infertility. The transcript variant LINC01960-201 has been studied for its involvement in modulating endometrial receptivity during the window of implantation. Mechanistically, LINC01960 may interact with microRNAs (including hsa-miR-608 and hsa-miR-760) and regulate expression of genes such as ADAMTS7. Experimental evidence suggests that altered LINC01960 expression can influence the molecular changes underlying endometrial stromal cell function and may serve as a biomarker of disease or reproductive dysfunction. LINC01960 is not a classical therapeutic target, such as a receptor or enzyme, but its role in reproductive biology is of increasing research interest

Other names

LINC01960LINC01960-201

Not applicable. No known drugs target this lncRNA; studied mechanisms relate to endogenous modulation of gene expression by microRNA interaction and regulatory pathways in cell biology