Long intergenic non-protein coding RNA 1965 (LINC01965)

Long intergenic non-protein coding RNA 1965 (LINC01965) is a human non-coding RNA gene, classified as a long intergenic non-coding RNA (lincRNA), meaning it is an autonomously transcribed, spliced RNA transcript longer than 200 nucleotides that does not overlap coding genes[1][5][3]. LincRNAs, including LINC01965, are thought to regulate gene expression at multiple levels, potentially affecting chromatin state, nuclear structure, or local transcriptional environments, often with high tissue and disease specificity[3][9]. There are currently no specific biological functions, disease mechanisms, or drug interactions directly attributed to LINC01965, although it has surfaced as a locus in large-scale genetic studies of neurological and psychiatric traits[2][4][6]. The functional and therapeutic relevance of LINC01965 remains to be established.

No therapeutic mechanism of action is reported for the direct targeting of LINC01965. Functional modulation, if it becomes of interest, would likely involve RNA interference, antisense oligonucleotides, or genome-editing approaches, but no clinical data support this at present[3][6][8].