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Long intergenic non-protein coding RNA 1975 (LINC01975)
- Target
- LINC01975
- Molecular classification
- Long non-coding RNA (lncRNA), Long intergenic non-coding RNA (lincRNA)
01
Overview
Long intergenic non-protein coding RNA 1975 (LINC01975) is an autonomously transcribed non-coding RNA that does not overlap protein-coding genes and is longer than 200 nucleotides. As a member of the long intergenic non-coding RNA (lincRNA) subclass, LINC01975 is believed to modulate the expression of neighboring genes, participate in chromatin architecture, and regulate transcription through various mechanisms. While the specific biological function of LINC01975 has not been experimentally characterized, lincRNAs in general are emerging as important regulators in tissue specificity and disease processes, notably cancer. There is evidence suggesting the dysregulation of certain lincRNAs, including LINC01975, may provide novel biomarkers for cancer diagnosis or prognosis, but no direct role as a therapeutic target or drug interaction has been established.
- Other names
- LINC01975long intergenic non-protein coding RNA 1975
02
Biological functions
Chromatin remodelingRegulation of gene expression in *cis* and *trans*Modulation of neighboring gene activityLikely tissue-specific regulatory roles (Note: Specific biological functions for LINC01975 are not defined, but these are the general roles of lincRNAs)
03
Disease associations
Cancer (LINC01975, as with many lincRNAs, has been associated broadly with cancer, with some data linking lncRNAs, including LINC01975, to endometrial cancer)Other (lncRNAs are studied in a range of diseases, but no clear evidence places LINC01975 specifically outside cancer roles)
04
Biomarkers
Potential biomarker for cancer, especially in the context of molecular profiling of cancers such as endometrial cancer
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