Long intergenic non-protein coding RNA 1977 (LINC01977)

Long intergenic non-protein coding RNA 1977 (LINC01977) is a long non-coding RNA (lncRNA) that does not code for a protein but plays an important regulatory role in gene expression. It is overexpressed in several cancers, including breast, colorectal, hepatocellular, and lung cancer, where it promotes tumor growth, cell migration, invasion, and chemoresistance. LINC01977 acts mainly as a molecular sponge for microRNAs (such as miR-212-3p), modulates the function and stability of proteins (for example, RBM39 and Notch2), and has been implicated as both a prognostic biomarker and a potential therapeutic target in oncology[2][4][6][8]. No currently approved drugs directly target LINC01977, but its influence on chemoresistance (e.g., to doxorubicin) highlights its relevance for future therapeutic development. The clinical utility of LINC01977 as a biomarker or direct target is under active investigation.

Other names

Long intergenic non-protein coding RNA 1977LINC01977

Molecular sponge/ceRNA: Sequesters specific microRNAs (e.g., miR-212-3p), thus derepressing target mRNAs and promoting oncogenic pathways. Protein binding: Interacts with RNA-binding proteins (e.g., RBM39) affecting protein stability (such as stabilizing Notch2 in liver cancer). Transcriptional and post-transcriptional regulation.