Long intergenic non-protein coding RNA 205 (LINC00205)

Long intergenic non-protein coding RNA 205 (LINC00205) is a long noncoding RNA (lncRNA) located on chromosome 21, primarily known for its upregulation in various cancers, including lung cancer, hepatocellular carcinoma, pancreatic cancer, and retinoblastoma[1][2][3]. LINC00205 modulates cancer cell phenotypes by promoting cell proliferation, inhibiting apoptosis, and enhancing migration, largely via the recruitment of the RNA-binding protein FUS, which helps stabilize the mRNA of cold shock domain containing E1 (CSDE1)[1]. Its expression correlates with a poor prognosis in some malignancies, making it a potential biomarker and emerging therapeutic target, though it is not currently targeted by any approved drugs[1][3].

Other names

LVBUlncRNA regulation via BCL6/urea cycleNCRNA00205LOC105372839LOC642852

Not targeted by drugs directly as of current data; endogenous mechanism involves recruitment of RNA-binding protein FUS to stabilize CSDE1 mRNA, up-regulating oncogenic pathways[1][3].