Long intergenic non-protein coding RNA 210 (LINC00210)

Long intergenic non-protein coding RNA 210 (LINC00210) is a long non-coding RNA (lncRNA), more specifically a long intergenic non-coding RNA (lincRNA), with no known protein-coding potential[1][5]. It is frequently copy number gained and highly expressed in liver tumor-initiating cells (TICs) and hepatocellular carcinoma[2][4]. LINC00210 promotes the self-renewal capacity and tumorigenicity of liver TICs by activating the Wnt/β-catenin signaling pathway. Mechanistically, LINC00210 interacts with CTNNBIP1 (β-catenin interacting protein 1), inhibiting its suppression of β-catenin, thus enabling β-catenin to stimulate transcription of Wnt target genes. This pathway is implicated in stemness, metastasis, and treatment resistance in liver cancer. Targeting the LINC00210–CTNNBIP1–Wnt/β-catenin axis is under investigation as a potential therapeutic approach for eliminating liver TICs and combating hepatocellular carcinoma progression[2][4]. There is no evidence it is a receptor, enzyme, or transporter; its primary mode of action is as an RNA regulatory factor.

Other names

RP11-72L13.1NCRNA00210LINC00210

In experimental systems, knockdown (e.g., via antisense oligonucleotides or CRISPRi) suppresses LINC00210 activity, leading to attenuation of Wnt/β-catenin signaling and reduced tumorigenic potential; inhibition of LINC00210 may disrupt the LINC00210–CTNNBIP1 interaction and restore inhibitory regulation of β-catenin