Long intergenic non-protein coding RNA 2123 (LINC02123)

Long intergenic non-protein coding RNA 2123 (LINC02123) is a human gene that produces a long intergenic non-coding RNA transcript. As part of the lincRNA class, it is distinguished from other lncRNAs by being transcribed from intergenic regions and not overlapping with protein-coding genes. LINC02123 and related lincRNAs play regulatory roles in gene expression, chromatin architecture, and RNA stability, often with considerable tissue specificity. Recent research highlights LINC02123 as a promising biomarker for lung cancer diagnosis, offering utility in non-invasive diagnostic models, including potential blood-based detection methods. It has been identified as a differentially expressed lncRNA in lung cancer datasets, with its downregulation potentially distinguishing tumor from normal samples. Its mechanisms are largely epigenetic or transcriptional, with no current evidence of peptide-coding potential or direct druggability. The clinical use of LINC02123 is primarily as a diagnostic biomarker rather than a therapeutic target.

Other names

LINC02123