Long intergenic non-protein coding RNA 2154 (LINC02154)

Long intergenic non-protein coding RNA 2154 (LINC02154) is a human long non-coding RNA (lncRNA) gene located on the X chromosome (chrX:13266047-13303452, hg38). It does not encode a protein, but instead produces non-coding RNA transcripts. LINC02154 has been identified as part of multi-lncRNA expression signatures associated with prognosis in certain cancers, such as esophageal cancer and as a marker associated with drug sensitivity phenotypes in some tumor types. It is also known as a Macrophage-Associated LncRNA (MALR), suggesting a potential—though not well-characterized—role in macrophage biology and immune regulation, but its exact molecular or physiological functions remain largely unelucidated in the scientific literature. There are no known drugs targeting this RNA directly, and no established mechanisms of action, though its differential expression may hold biomarker potential for malignancies. The HGNC-approved gene symbol is LINC02154; the full name is long intergenic non-protein coding RNA 2154. Aliases include GS1-600G8.5, MALR, and Macrophage-Associated LncRNA. It is a long non-coding RNA gene, not a protein-coding receptor, enzyme, or druggable target. Described disease associations are primarily as a prognostic biomarker in cancer, not as a direct drug target or mechanistically defined pathway member. No references available for drugs, direct functional mechanisms, or specific safety issues related to this RNA. Its annotation as “Macrophage-Associated LncRNA” suggests a functional link to immune cell regulation, but published functional data remain sparse.

Other names

GS1-600G8.5MALRMacrophage-Associated LncRNA