Long intergenic non-protein coding RNA 2167 (LINC02167)

**Long intergenic non-protein coding RNA 2167 (LINC02167)** is a long non-coding RNA (lncRNA) located in intergenic genomic regions, meaning it does not encode a protein. It is significantly upregulated in colorectal cancer tissues and is associated with advanced clinical features and poor prognosis. Functionally, LINC02167 is predominantly cytoplasmic and acts as a molecular scaffold, forming complexes with RNA-binding proteins YBX1 and ILF3 to stabilize KSR1 mRNA through NSUN2-mediated 5-methylcytosine (m5C) modification, thereby enhancing ERK/MAPK pathway signaling and promoting cancer cell migration, invasion, and metastasis. Myc-driven transcription acts upstream to upregulate its expression in cancer. LINC02167 is considered a promising therapeutic target in metastatic colorectal cancer, although no approved drugs currently target it directly[1][2].

Other names

FLJ26245LINC02167

RNA-mediated scaffolding of RNA-binding proteins (YBX1, ILF3) to promote KSR1 mRNA stability; Positive regulation of ERK/MAPK pathway signaling