Long intergenic non-protein coding RNA 2188 (LINC02188)

Long intergenic non-protein coding RNA 2188 (LINC02188) is a human long intergenic non-coding RNA gene, categorized as a lincRNA, meaning it produces autonomously transcribed non-coding RNAs longer than 200 nucleotides that do not overlap with protein-coding genes. LINC02188 may be involved in regulating gene expression through epigenetic mechanisms, such as chromatin remodeling, transcriptional regulation, or modulation of RNA stability. In recent research, LINC02188 has been associated with breast cancer biology, particularly as a potential marker and modulator within specific subtypes (notably Basal and Normal). Its expression levels correlate with key immune checkpoint genes and immune cell infiltration, suggesting roles in the tumor microenvironment and immune surveillance. LINC02188 is considered one of several non-coding RNAs with possible utility as cancer subtype biomarkers and as future therapeutic targets, but its biological functions and mechanisms of action remain incompletely characterized. No direct pharmacological agents are currently known to target LINC02188, and safety concerns or off-target effects have not been reported.

Other names

LINC02188ENSG00000261175CTD-2015G9.216q24.1