Target intelligence / Profile preview

Long intergenic non-protein coding RNA 2210 (LINC02210)

Target
LINC02210
Molecular classification
Long non-coding RNA (lncRNA), Other
01

Overview

Long intergenic non-protein coding RNA 2210 (LINC02210) is a long non-coding RNA (lncRNA) located on human chromosome 17. It does not encode a protein, but instead may function in the regulation of gene expression or RNA metabolism. Increased expression in pancreatic β-cells suggests a possible role in insulin sensitivity. Genome-wide association studies have linked genetic loci overlapping LINC02210 to various phenotypes, including red blood cell traits, primary biliary cirrhosis, intelligence, and mathematical ability. LINC02210 is not currently considered a therapeutic target, receptor, enzyme, or similar tractable protein, but serves as a potential locus of interest for biomarker and disease association studies[1][5][7][10][11].

Other names
C17orf69CRHR1-IT1FLJ25168C17ORF69GC17P045628
02

Biological functions

RNA metabolic processRNA processingNucleic acid metabolic processpotentially involved in regulation of gene expression
03

Disease associations

Koolen-De Vries syndromeRetinitis pigmentosaPrimary biliary cirrhosispossibly involved in insulin sensitivity and cognitive function
04

Biomarkers

Genetic variants in/near LINC02210 associated with traits such as corpuscular hemoglobin concentration, intelligence, mathematical ability, and primary biliary cirrhosis in GWAS

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