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Long intergenic non-protein coding RNA 2220 (LINC02220)
- Target
- LINC02220
- Molecular classification
- Long non-coding RNA (lncRNA), Long intergenic non-coding RNA (lincRNA)
01
Overview
Long intergenic non-protein coding RNA 2220 (LINC02220) is a non-coding RNA gene located in the human genome, not translated into protein and classified within the lincRNA family. LINC02220 is expressed in human sperm and is upregulated in male infertility conditions characterized by reduced or abnormal sperm motility and morphology, such as asthenozoospermia and terato-asthenozoospermia. Its elevated expression is associated with downregulation of DNAH5, a gene essential for proper flagellum function and sperm movement. LINC02220 functions as an epigenetic regulator, most likely modulating gene expression at the transcriptional or chromatin level, and is considered a molecular factor rather than a direct therapeutic target
- Other names
- LINC02220Long intergenic non-protein coding RNA 2220
02
Mechanism of action
Not applicable for drugs, as there are no interacting therapeutics; mechanism of endogenous function is negative regulation of DNAH5 gene expression, likely by epigenetic or post-transcriptional means
03
Biological functions
Negative regulation of DNAH5 gene expression, affecting sperm motility and morphology in asthenozoospermia and terato-asthenozoospermiaEpigenetic gene regulation; likely operates through interaction with chromatin, transcriptional regulatory elements, or neighboring gene promoters, consistent with known lincRNA functionsMay participate in processes such as cell differentiation or chromatin remodeling, based on lincRNA general mechanisms
04
Disease associations
Male infertility: Specifically, involvement in asthenozoospermia and terato-asthenozoospermia by influencing sperm motility via DNAH5 downregulationPotential epigenetic marker or contributor in broader reproductive and testicular dysfunctions
05
Safety considerations
Not applicable. No therapeutic interventions or drug targeting exist for LINC02220, so safety or off-target concerns are not reported
06
Interacting drugs
None identified. There are currently no drugs described in the literature or major databases directly targeting LINC02220
07
Biomarkers
Upregulation of LINC02220 in sperm may serve as a molecular biomarker for asthenozoospermia and terato-asthenozoospermia
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