Long intergenic non-protein coding RNA 2240 (LINC02240)

Long intergenic non-protein coding RNA 2240 (LINC02240) is a human lncRNA gene transcript with no protein-coding potential. Functionally, LINC02240 acts as a molecular sponge for miR-7-5p, which leads to upregulation of EGFR expression, thereby promoting cell invasion and migration in non-small cell lung cancer. Its expression profile and role in modulating miRNA networks indicate possible utility as a biomarker and a promising therapeutic target in oncology. However, its molecular characterization and therapeutic potential require further direct validation, as most evidence derives from studies of related lncRNAs and from gene expression analyses. LINC02240 is classified under long non-coding RNA genes and is not a protein-coding gene, nor does it fit into traditional families like receptors, enzymes, or ion channels. Most information is based on transcriptomic databases and cancer biology studies documenting the regulatory effects of similar lincRNAs. There is currently no known drug approved or in active clinical development that specifically targets LINC02240, though its modulation of cancer cell behavior suggests future potential in precision medicine approaches.

Other names

LINC02240long intergenic non-protein coding RNA 2240

miRNA sponge (regulates miR-7-5p; thus may indirectly alter EGFR signaling and gene expression, which impacts cell migration and invasion in cancer models)