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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 2273 (LINC02273)
- Target
- LINC02273
- Molecular classification
- Long non-coding RNA (lncRNA), Intergenic lncRNA
01
Overview
Long intergenic non-protein coding RNA 2273 (LINC02273) is a nuclear-localized long non-coding RNA that is significantly upregulated in several cancers, including hepatocellular carcinoma and breast cancer. This molecule promotes tumor proliferation, stemness, migration, invasion, and anti-apoptosis via stabilizing β-catenin and activating the Wnt/β-catenin signaling pathway. LINC02273 is considered a potential therapeutic target as its knockdown attenuates malignant properties in vitro; it is also a candidate biomarker for cancer diagnosis and prognosis. Clinical application faces challenges linked to the specificity of targeting and risk of off-target toxicity, given the importance of the Wnt/β-catenin pathway in normal tissue homeostasis[2][3].
- Other names
- LINC02273Long intergenic non-protein coding RNA 2273HGNC:53188NCBI Gene:100996286Ensembl:ENSG00000245954
02
Mechanism of action
Transcriptional suppression by knockdown (siRNA or antisense oligos can be used to reduce LINC02273 expression); Inhibition of β-catenin stabilization (targeting LINC02273 reduces β-catenin nuclear stability and activity, thereby suppressing Wnt/β-catenin signaling in tumors)
03
Biological functions
Transcriptional regulationCell proliferationCell migration and invasionAnti-apoptosisEpigenetic regulation
04
Disease associations
Cancer
05
Safety considerations
Systemic toxicity from pathway interferenceTherapeutic specificity
06
Biomarkers
LINC02273 expression level
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