Long intergenic non-protein coding RNA 2308 (LINC02308)

LINC02308 is a human long intergenic non-coding RNA recognized for its significant overexpression in glioma tissue and association with poor patient prognosis. It functions primarily by binding to specific microRNAs such as miR-30e-3p, thereby modulating their activity and affecting downstream signaling pathways like AKT/mTOR. Through these mechanisms, LINC02308 can promote tumor cell proliferation, inhibit apoptosis, and play an oncogenic role in cancer biology. While not a classical drug target, it receives growing attention as a potential biomarker and mediator in the regulation of gene expression and disease pathways.

For interacting molecules: Acts by sequestering miR-30e-3p, upregulating TM4SF1, subsequently activating the AKT/mTOR pathway