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Long intergenic non-protein coding RNA 2389 (LINC02389)

Target: LINC02389
Molecular classification: Other (lncRNA, long non-coding RNA)

Overview

Long intergenic non-protein coding RNA 2389 (LINC02389) is a human long non-coding RNA gene localized to chromosome 12. It does not encode a protein, but rather functions at the RNA level. LINC02389 has been detected in gene fusion events in cancers such as carcinoma ex pleomorphic adenoma (HMGA2::LINC02389). Its biological functions have not been comprehensively described, but lncRNAs in general may regulate gene expression, chromatin structure, and alternative splicing. There are currently no known drugs or therapies directed at LINC02389.

Other names: FLJ41278ENSG00000255693Entrez Gene ID 400046

Biological functions

Involvement in gene fusion events (e.g., HMGA2::LINC02389)Potential relevance to carcinoma ex pleomorphic adenoma through gene fusion eventsRegulation of gene expression (general lncRNA function)Regulation of splicing (general lncRNA function)Regulation of chromatin structure (general lncRNA function)

Disease associations

Cancer (implicated by HMGA2::LINC02389 chromosomal fusion in carcinoma ex pleomorphic adenoma)Potential associations in esophageal cancer based on alternative splicing events

Safety considerations

None reported

Biomarkers

LINC02389 itself (as a research biomarker in cancer profiling)Fusion events involving LINC02389 (such as HMGA2::LINC02389, as a research biomarker in carcinoma ex pleomorphic adenoma)

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