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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 2392 (LINC02392)
- Target
- LINC02392
- Molecular classification
- Other (Long non-coding RNA)
01
Overview
Long intergenic non-protein coding RNA 2392 (LINC02392) is a human long non-coding RNA gene located on chromosome 12. It is not protein-coding and has been described in the context of kidney cancer as being associated with mechanisms of resistance to the tyrosine kinase inhibitor Sunitinib. LINC02392 is sometimes called lncRNA-ECVSR, referencing proposed involvement in ERβ/CSC/VM signaling and vascular mimicry, but the biological functions and clinical implications are still under investigation. It is cataloged in common gene databases (NCBI Gene, Ensembl, HGNC).
- Other names
- lncRNA-ECVSRlncRNA of ERβ/CSC/VM signaling related to Sunitinib ResistancelncRNA of ERbeta/CSC/VM signaling related to Sunitinib Resistance
02
Mechanism of action
Not a direct drug target; but may modulate pathways (such as ERβ/CSC/VM signaling) affecting Sunitinib resistance. Mechanisms are related to regulation of gene expression affecting cell sensitivity to Sunitinib.
03
Biological functions
Other (Emerging evidence suggests involvement in cancer-related signaling and drug resistance, particularly in clear cell renal cell carcinoma)
04
Disease associations
Cancer (specifically related to mechanisms of resistance to Sunitinib in renal cell carcinoma)Other (potential involvement in cell signaling changes)
05
Safety considerations
As an endogenous non-coding RNA, no specific safety issues, but lncRNA-based therapeutics have general challenges such as off-target effects and delivery.
06
Interacting drugs
Sunitinib
07
Biomarkers
Potentially a biomarker for Sunitinib resistance in renal cell carcinoma (research context)
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