Long intergenic non-protein coding RNA 242 (LINC00242)

Long intergenic non-protein coding RNA 242 (LINC00242) is a long non-coding RNA (lncRNA) categorized specifically as a long intergenic non-coding RNA, meaning it is transcribed from genomic regions not overlapping protein-coding genes[1]. LINC00242 functions in part by modulating gene expression and has been shown to play an oncogenic role in gastric cancer by promoting cell proliferation and aerobic glycolysis through the LINC00242/miR-1-3p/G6PD axis; it acts as a molecular sponge for miR-1-3p, thereby permitting increased expression of G6PD and promoting metabolic reprogramming in cancer cells[2]. LINC00242 is not a protein, receptor, enzyme, or traditional drug target, but is significant for its function in cancer progression and possible value as a biomarker. Its dysregulation is associated with worse outcomes in cancer models, supporting its emerging significance in tumor biology[2].

Other names

LINC00242C6orf122NCRNA00242FLJ31451dJ266L20.5Putative uncharacterized protein encoded by LINC00242

Regulation through the LINC00242/miR-1-3p/G6PD axis; LINC00242 acts as a molecular sponge for miR-1-3p, thereby relieving miR-1-3p-mediated suppression of G6PD expression, affecting proliferation and glycolysis in gastric cancer cells[2]