Long intergenic non-protein coding RNA 2428 (LINC02428)

Long intergenic non-protein coding RNA 2428 (LINC02428) is a long noncoding RNA highly expressed in normal liver tissue but downregulated in hepatocellular carcinoma (HCC)[1][2]. LINC02428 functions as a tumor suppressor by inhibiting proliferation, migration, and metastasis of HCC cells both in vitro and in vivo[1][2]. Mechanistically, LINC02428 binds to insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) in the cytoplasm, which prevents IGF2BP1 from stabilizing lysine demethylase 5B (KDM5B) mRNA, thereby decreasing KDM5B expression and disrupting a pro-tumorigenic positive feedback loop between KDM5B and IGF2BP1[1][2]. Low LINC02428 expression in HCC is associated with poor prognosis, and its expression may serve as a biomarker for prognosis in liver cancer patients[1][2]. No interacting drugs or direct mechanisms of drug action have been described, and there are currently no documented therapeutic safety concerns related specifically to targeting LINC02428.

Other names

LINC02428long intergenic noncoding RNA 2428