Long intergenic non-protein coding RNA 2432 (LINC02432)

Long intergenic non-protein coding RNA 2432 (LINC02432) is a long non-coding RNA implicated in the regulation of cancer cell metabolism, particularly in pancreatic adenocarcinoma. As part of a regulatory axis with miR-98-5p and HK2, LINC02432 promotes glycolysis and suppresses ferroptosis, thereby enhancing tumor cell proliferation and survival. Its expression is correlated with immune infiltration and tumor mutation burden, highlighting its role as a risk stratification marker and potential therapeutic target. Elevated LINC02432 suggests a worse prognosis, and patients with high expression may show increased sensitivity to certain kinase inhibitors[2][4].

Other names

LINC02432long intergenic non-coding RNA 2432

Acts as a competing endogenous RNA (ceRNA) by sponging miR-98-5p, leading to upregulation of HK2 and enhanced glycolytic activity in cancer cells; disruption of ferroptosis; modulation of immune cell infiltration and chemokine expression