Long intergenic non-protein coding RNA 2487 (LINC02487)

Long intergenic non-protein coding RNA 2487 (LINC02487) is a long non-coding RNA (lncRNA) that functions as a tumor suppressor in several human cancers, including oral squamous cell carcinoma and cervical cancer. LINC02487 is generally downregulated in tumor tissues, with its expression inversely linked to cancer cell proliferation, migration, and invasion. Mechanistically, it acts through key cancer-related pathways; for example, in cervical cancer it upregulates phosphatase and tensin homolog (PTEN) and inhibits the Akt/mTOR signaling pathway, and in oral squamous cell carcinoma it directly binds USP17 and affects the USP17–SNAI1 axis, modulating EMT and metastasis. Its potential clinical utility is as a biomarker for cancer presence or metastasis, and possibly as a future RNA-based therapeutic target. LINC02487 is classified as a long non-coding RNA, and not as a receptor, enzyme, or traditional drug target; it exerts regulatory control via interactions with protein-coding genes and mediator proteins.

Other names

LINC02487long non-coding RNA LINC02487lncRNA LINC02487

Not applicable; LINC02487 is a non-protein-coding RNA and is not directly targeted by drugs, but regulates other targets (e.g., PTEN, USP17) that could be therapeutically relevant