Long intergenic non-protein coding RNA 2532 (LINC02532)

Long intergenic non-protein coding RNA 2532 (LINC02532) is a long non-coding RNA (lncRNA) that does not encode a protein but plays a regulatory role in gene expression. It is highly expressed in several cancer types, notably clear cell renal cell carcinoma (ccRCC) and gastric cancer, where it acts as an oncogenic RNA promoting cell proliferation, migration, and invasion[2][3]. Mechanistically, LINC02532 is located primarily in the cytoplasm and acts as a competing endogenous RNA (ceRNA), sponging specific microRNAs (such as miR-654-5p and miR-129-5p), which allows for the upregulation of oncogenic pathways and transcription factors like YY1[2][3]. In ccRCC, its knockdown increases radiosensitivity, suggesting a role in radioresistance and supporting its candidacy as a potential therapeutic target for sensitizing tumors to radiation[2]. In gastric cancer, high LINC02532 expression correlates with advanced tumor stage, poorer differentiation, and worse patient prognosis, implicating it as a potential biomarker and therapeutic target[3]. The broad functional spectrum and context-dependent roles of lncRNAs like LINC02532 present both opportunities and challenges for clinical development.

Other names

LINC02532

Modulates cellular radiosensitivity via a ceRNA (competing endogenous RNA) mechanism by sponging microRNAs (miR-654-5p in ccRCC, miR-129-5p and miR-490-5p in gastric cancer); Indirect regulation of oncogenic transcription factors (e.g., YY1 via miRNA sponging)