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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 2577 (LINC02577)
- Target
- LINC02577
- Molecular classification
- Long non-coding RNA (lncRNA), Non-coding RNA, Other
01
Overview
Long intergenic non-protein coding RNA 2577 (LINC02577) is a human long non-coding RNA not translated into protein. It has been identified as playing a role in colorectal cancer through the promotion of lymphangiogenesis, which is a key step in cancer metastasis, and is also recognized as a survival-predictive biomarker in kidney cancer[6][7][5]. LINC02577 acts by mechanisms typical of lncRNAs, often involving the regulation of gene expression and potentially functioning as a "sponge" for microRNAs[2]. There is ongoing research into its precise molecular role in tumor biology, prognosis, and its value as a biomarker, but it is not currently considered a direct druggable target[7][6][10].
- Other names
- AC002384.1SLINKYCLANSurvival-predictive LincRNA in Kidney cancerColorectal cancer lymphangiogenesis-associated lncRNA
02
Mechanism of action
Not applicable for drugs, as LINC02577 is not a direct pharmacological target[6][7]
03
Biological functions
Regulation of lymphangiogenesis (formation of new lymphatic vessels) in colorectal cancer[6][5][7]Potential regulation of cell proliferation and metastasis[7]May function as a molecular "sponge" for microRNAs, affecting downstream gene regulation[2]
04
Disease associations
CancerColorectal cancer (lymphangiogenesis, prognosis, metastasis)[6][5][7][2]Kidney cancer (prognostic biomarker; especially related to patient survival)[6][8][5]
05
Safety considerations
None reported. As LINC02577 is not a current therapeutic target, no therapeutic safety concerns have been described[6][8][5]
06
Biomarkers
Prognostic biomarker in kidney cancer ("novel lincRNA SLINKY is a prognostic biomarker in kidney cancer")[6]Associated with lymphangiogenesis in colorectal cancer, suggesting potential as a biomarker for metastasis risk, although not yet standard in clinical use[6][5][10]
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