long intergenic non-protein coding RNA 2587 (LINC02587)

Long intergenic non-protein coding RNA 2587 (LINC02587) is a human long non-coding RNA gene. It is approved under HGNC:50672, also known as MEOX2-AS1 or MEOX2 antisense RNA 1 (head to head). LINC02587 is located on chromosome 7p21.2 and harbors CpG islands that regulate its methylation-dependent expression. It is upregulated in several human cancers, where its silencing induces cell cycle arrest, apoptosis, and ferroptosis, particularly via the CoQ-FSP1 pathway which regulates oxidative stress-induced cell death. LINC02587 thus serves both as a potential prognostic biomarker and as a candidate therapeutic target, most notably in glioma and cervical cancer. Its mechanism involves influencing cellular proliferation, migration, and apoptosis, and modulating the cellular resistance to ferroptosis through FSP1 and CoQ10B. There is ongoing research into small molecule or RNA-based therapies that could modulate its expression, though clinical validation is still required.

Other names

MEOX2-AS1MEOX2 antisense RNA 1 (head to head)LINC02587

Drugs such as siRNAs targeting LINC02587 cause silencing of LINC02587, which leads to increased ferroptosis via suppression of the CoQ-FSP1 pathway and upregulation of cell death in glioma cells. iFSP1 inhibits the FSP1/CoQ axis, thereby increasing susceptibility of cancer cells to ferroptosis when LINC02587 is suppressed.