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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 265 (LINC00265)
- Target
- LINC00265
- Molecular classification
- Long non-coding RNA, Intergenic lncRNA, Non-protein coding gene
01
Overview
Long intergenic non-protein coding RNA 265 (LINC00265) is a human long non-coding RNA gene that does not encode a protein but may regulate the transcription of genes nearby or at distant loci[3][5][6]. LINC00265 is upregulated in various cancers, including hepatocellular carcinoma, where it promotes malignant cell behaviors by interacting with E2F1 transcription factor and enhancing transcription of cyclin-dependent kinase 2 (CDK2)[6]. LINC00265 may serve as a prognostic biomarker for certain malignancies but is not a conventional therapeutic target such as a receptor, enzyme, or transporter[3][6].
- Other names
- NCRNA00265LINC00265-3PNCRNA00265-3PLINC00265-2Plong intergenic non-protein coding RNA 265-3long intergenic non-protein coding RNA 265-2
02
Biological functions
Regulation of transcriptionRegulation of cell proliferationPromotion of cancer cell migration and invasion
03
Disease associations
Cancer (notably hepatocellular carcinoma)
04
Biomarkers
Potential biomarker for prognosis in hepatocellular carcinoma
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