Long intergenic non-protein coding RNA 27 (LINC00027)

This gene, under the aliases “HPYR1,” “LINC00027,” “HPRG1,” “NCRNA00027,” and “non-protein coding RNA 27,” is annotated as a *long non-coding RNA (lncRNA)* with no protein-coding capacity. There is no validated functional or therapeutic literature associating this lncRNA with canonical *Helicobacter pylori* response pathways, nor is it defined as a receptor, enzyme, transporter, or classic drug target. It is not listed in major pharmacological or therapeutic target compendia. Curation in public databases (such as NCBI Gene, Ensembl, and GENCODE) references its existence as a long intergenic non-coding RNA, but with largely **unknown biological function** and without strong evidence for disease relevance or targetability. **Assessment** - This “target” is not a validated therapeutic target or receptor; it is indexed as a non-coding RNA of currently undetermined function, with no evidence of relevance to *H. pylori* response in the context of current molecular medicine. - The submitted list conflates *Helicobacter pylori* itself (a bacterial pathogen) with an uncharacterized human gene annotation (“LINC00027”), which leads to confusion; the names are not well established in the biomedical literature. If you are seeking information on *Helicobacter pylori* pathogenesis, regulatory systems, or non-coding RNAs implicated in the bacterial response (such as pH-responsive transcriptional regulation in *H. pylori*[1] or small bacterial RNAs such as HPnc4160[2]), these are separate and well-defined topics unrelated to the above human gene symbol. The entry is therefore not a canonical or therapeutically actionable target.

Other names

HPRG1NCRNA00027LINC00027non-protein coding RNA 27HPYR1Helicobacter pylori responsive 1 (non-protein coding)