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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 273 (LINC00273)
- Target
- LINC00273
- Molecular classification
- Long non-coding RNA (lncRNA)
01
Overview
LINC00273 is a long non-coding RNA transcribed from an intergenic region, primarily associated with the promotion of cancer metastasis and cellular invasion. It is notably upregulated in invasive and poorly differentiated cancer tissues across multiple organs, and its promoter features a unique parallel G-quadruplex structure targeted by the molecule M2, which suppresses LINC00273 expression and metastatic activity. The biological activity of LINC00273 is closely linked to large-scale transcriptional and epigenetic regulation, appearing to serve as a biomarker for cancer staging and a promising therapeutic target due to its apparent role as an inducer of metastasis. Elevated expression correlates with tumor aggressiveness, and knockdown experiments demonstrate significant reduction of migratory and invasive properties in cancer cells.
- Other names
- TOPNCRNA00273-1NCRNA00273non-protein coding RNA 273-1
02
Mechanism of action
M2 targets a unique (4n-1) G-quadruplex structure in the LINC00273 promoter, downregulating its expression and inhibiting EMT (epithelial–mesenchymal transition) and metastasis
03
Biological functions
Promotes cancer cell proliferation, invasion, and metastasisInvolved in cell signaling pathways, including interaction with transforming growth factor beta (TGF-β)Regulation of gene expression, possibly through unique promoter G-quadruplex structures
04
Disease associations
Cancer (roles in ovarian, oral squamous cell carcinoma, breast, colon, prostate, intestine, uterus, and more)Biomarker for cancer prognosis and metastasis staging
05
Safety considerations
As with other RNA-targeted therapies, potential challenges may include off-target effects, delivery to target tissues, and impact on normal gene regulation; specific concerns for LINC00273 remain underinvestigated
06
Interacting drugs
M2 (a salt molecule of bis Schiff base)
07
Biomarkers
LINC00273 expression levels (used to stage cancer progression and metastasis)
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