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Long intergenic non-protein coding RNA 2747 (LINC02747)
- Target
- LINC02747
- Molecular classification
- Long non-coding RNA (lncRNA), Long intergenic non-coding RNA (lincRNA), Other (non-protein coding transcript)[1][3][4]
01
Overview
Long intergenic non-protein coding RNA 2747 (LINC02747) is a long non-coding RNA (lncRNA) gene located on chromosome 11q13, encoded at 11:69475567-69481545[2]. It is classified as a lincRNA—meaning a long RNA transcript (>200 nucleotides) that does not overlap with protein-coding genes and lacks an open reading frame for protein synthesis[4][6]. While the specific biological role of LINC02747 remains uncharacterized, lincRNAs are generally recognized for their potential to regulate gene expression at multiple levels, both in *cis* (nearby genes) and *trans* (distant genes), and for their involvement in diverse cell processes such as cell-cycle regulation, development, and stress responses in other contexts[6]. LINC02747 has been shown to be the most strongly downregulated lncRNA in psoriatic lesions, indicating a possible role or association with psoriasis pathophysiology[5]. There is no evidence that LINC02747 is currently a direct therapeutic target, nor are any drug interactions or mechanisms established[1][3][4][5].
- Other names
- AP000439.3CUPID2AP000439.2CCND1-upstream intergenic DNA repair 2CUPID1LINC02747
02
Biological functions
Gene regulation (potentially through transcriptional or post-transcriptional mechanisms, as is the case for lincRNAs generally)[6]Other (no specific function directly established for LINC02747)
03
Disease associations
Other (LINC02747 is strongly differentially expressed in psoriasis, being the most highly downregulated lncRNA in lesional skin vs. healthy control)[5]
04
Biomarkers
Differential downregulation in psoriatic skin compared to healthy skin suggests biomarker potential for disease state/severity[5]
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