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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 2940 (LINC02940)
- Target
- LINC02940
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
Long intergenic non-protein coding RNA 2940 (LINC02940), also known as CCMAlnc (colorectal cancer metastasis-associated lncRNA), is a long non-coding RNA that is upregulated in colorectal cancer tissues compared to normal tissue, with expression levels further increased in metastatic colorectal cancers. CCMAlnc promotes colorectal cancer malignancy by acting as a competing endogenous RNA (ceRNA) that stabilizes the expression of HES6 through downregulation of miR-5001-5p. Functional studies have shown that downregulation of CCMAlnc suppresses colorectal cancer cell proliferation and invasion, while overexpression enhances these malignant properties. Elevated expression of CCMAlnc is associated with poor prognosis in colorectal cancer patients, suggesting its utility as a biomarker and its potential as a therapeutic target in colorectal cancer metastasis[1][3].
- Other names
- CCMAlncColorectal cancer metastasis-associated lncRNA
02
Biological functions
Competing endogenous RNA activity (ceRNA)Regulation of gene expressionRegulation of metastasis pathwaysPromotion of cell proliferationPromotion of cell invasionRegulation of stem cell pathways
03
Disease associations
CancerColorectal cancer metastasis
04
Safety considerations
Not established; no drugs targeting LINC02940 are currently clinically availablePotential risk includes involvement in cancer progression, specifically metastasis and growth
05
Biomarkers
Potential biomarker for metastasis prediction in colorectal cancerProposed prognostic factor for poor survival in colorectal cancer patients
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