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Target intelligence / Profile preview
Long intergenic non-protein coding RNA 2986 (LINC02986)
- Target
- LINC02986
- Molecular classification
- Long non-coding RNA (lncRNA), Long intergenic non-protein coding RNA (lincRNA), Other
01
Overview
Long intergenic non-protein coding RNA 2986 (LINC02986), also known as lncZBTB10, is a long intergenic non-coding RNA (lincRNA) that is overexpressed in prostate cancer and associated with poor clinical outcomes[1][4]. It facilitates androgen receptor (AR) activity in prostate cancer cells by promoting S-palmitoylation and the formation of nuclear biomolecular condensates, thereby contributing to tumor growth and resistance to the drug abiraterone[4]. LINC02986 exemplifies the class of lincRNAs, which typically function in gene regulation, chromatin architecture, and can act as tissue-specific regulators; however, LINC02986 is not a classical therapeutic target such as a receptor, enzyme, or transporter[3][4]. Evidence currently supports its role as a regulator and potential biomarker rather than as a direct target for drug interactions.
- Other names
- lncZBTB10
02
Biological functions
Regulation of transcriptionRegulation of androgen receptor functionChromatin remodelingOther
03
Disease associations
CancerProstate cancerOther
04
Biomarkers
Overexpression is associated with poor prognosis in prostate cancerPotential biomarker for abiraterone resistance in prostate cancer
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