Long intergenic non-protein coding RNA 2996 (LINC02996)

Long intergenic non-protein coding RNA 2996 (LINC02996) is a human long non-coding RNA (lncRNA) gene located on chromosome 5 (GRCh38: 5:42153219-42188157)[1][3][6]. It is recognized by the HGNC with approved gene symbol LINC02996 and affiliated with the lncRNA gene class[1][7]. Synonyms include IGF1R/AK000840 fusion and TCONS_00010315[6]. Its biological function is not well defined and it has not been established as a direct therapeutic target, receptor, enzyme, transporter, or other druggable protein[1][7][12]. Some database entries indicate expression or methylation in chronic lymphocytic leukemia and presence in cancer genomic studies, but there is no evidence for direct targeting with drugs or as a biomarker[12][9][11]. As a long non-coding RNA, it may potentially play a regulatory role in gene expression or chromatin modification, but experimental evidence specific to this transcript is lacking in current databases. Some sources list it in the context of fusion genes (e.g., IGF1R/AK000840 fusion), but details or functional consequences of such fusions are not described in the search results. There is no evidence for established pharmacological manipulation of this lncRNA. Despite the presence of "IGF1R" in one alias, this is not the insulin-like growth factor 1 receptor itself, nor a conventional receptor molecule. No interacting drugs, mechanisms of action, or approved biomarker status are reported in any functional or pharmacological databases[6][7][12].

Other names

IGF1R/AK000840 fusionTCONS_00010315LINC02996[1][5][6][7]

Not applicable