Long intergenic non-protein coding RNA 301 (LINC00301)

Long intergenic non-protein coding RNA 301 (LINC00301) is a long non-coding RNA located at 11q12.2, spanning 864 nucleotides and consisting of 7 exons[2]. It is transcribed but not translated into protein and is classified as an intergenic lncRNA, positioned between protein-coding genes[2][5]. LINC00301 is highly upregulated in non-small cell lung cancer (NSCLC) tissues and cell lines, where it promotes oncogenic processes, including increased cell proliferation, migration, invasion, evasion of apoptosis, and facilitation of tumor growth in animal models[2][4]. Mechanistically, LINC00301 contributes to immunosuppression in the tumor microenvironment by increasing regulatory T cell (Treg) infiltration and reducing cytotoxic CD8+ T cell abundance, promoting disease progression. At the molecular level, LINC00301 acts in both the nucleus and cytoplasm: it scaffolds epigenetic proteins such as EZH2 to repress tumor suppressor genes (EAF2) via chromatin modification and acts as a ceRNA for miR-1276 to enhance HIF1α signaling[2][4]. LINC00301 is considered a potential therapeutic target and biomarker in cancer, especially NSCLC, given its association with poor prognosis and tumor aggressiveness. No clinically approved drugs currently target LINC00301 directly, but its mechanisms suggest future therapeutic intervention points[2][4].

Other names

C11orf64NCRNA00301LINC00301long intergenic non-coding RNA 00301

Acts as a scaffold for enhancer of zeste homolog 2 (EZH2) facilitating chromatin remodeling; Functions as a competing endogenous RNA (ceRNA) for miR-1276, regulating HIF1α expression; Modulates FOXC1-mediated expression; Promotes H3K27me3 modification at EAF2 promoter, destabilizing pVHL and thereby upregulating HIF1α