Long intergenic non-protein coding RNA 302 (LINC00302)

Long intergenic non-protein coding RNA 302 (LINC00302) is a long non-coding RNA (lncRNA) classified specifically as a long intergenic non-coding RNA (lincRNA). It is encoded on human chromosome 1 (loc: 1q21.3; NCBI Gene ID 388699) and is not translated into a protein. LINC00302 has been identified as a candidate regulatory RNA in skin biology, particularly implicated in the modulation of skin barrier function and inflammatory signaling. It is associated with processes such as tissue remodeling and wound healing, with evidence that overexpression in dermal fibroblasts enhances cell viability and upregulates critical extracellular matrix components, suggesting a function in skin integrity and recovery from injury. LINC00302 has also been found differentially expressed in settings of skin inflammation (e.g., atopic dermatitis, psoriasis) and tissue repair, indicating involvement in these biological pathways. No current evidence defines it as a direct therapeutic target (i.e., not a receptor, enzyme, transporter, or transcription factor), and there are no known drugs that directly interact with it or validated mechanisms of action for pharmacological modulation of LINC00302. There are no well-documented safety concerns at this time.

Other names

XP33C1orf46NCRNA00302xp33LINC00302