Long intergenic non-protein coding RNA 305 (LINC00305)

LINC00305 is a human long noncoding RNA (lncRNA), 69 kb in length and located at chromosome 18q22.1, with minimal protein-coding potential[1][2][3]. It is primarily expressed in monocytes and is significantly upregulated in atherosclerotic plaques[1][2][6]. Functional research indicates that LINC00305 plays a pro-inflammatory role by promoting the expression of inflammation-related genes in monocyte cell models, notably through activation of the NF-κB pathway. Mechanistically, LINC00305 interacts with the transmembrane protein lipocalin-1 interacting membrane receptor (LIMR) and strengthens the interaction between LIMR and aryl-hydrocarbon receptor repressor (AHRR), enhancing AHRR’s expression and nuclear localization. This promotes NF-κB activation and leads to pro-inflammatory cytokine expression and vascular smooth muscle cell phenotype switching, critical steps in atherogenesis[1][2][4][6]. Currently, LINC00305 is not a validated therapeutic target or druggable receptor, but it is an emerging molecule of interest for biomarker research and understanding the regulation of inflammation in vascular disease[1][6].

Other names

C18orf20NCRNA00305MGC39571HsT1235