Long intergenic non-protein coding RNA 317 (LINC00317)

Long intergenic non-protein coding RNA 317 (LINC00317) is a long non-coding RNA gene located at cytogenetic region 21q21.1 and annotated as ENSG00000238265 in Ensembl and 378828 in NCBI Gene. LINC00317 does not encode a protein but contributes to gene regulation at the RNA level, primarily through modulating transcription, epigenetic states, or interactions with proteins and other RNAs. Recent evidence implicates LINC00317 as a candidate molecular biomarker for cancer diagnosis and stratification, especially in non-small cell lung cancer, where it has been used in machine learning classification models to distinguish cancerous from normal tissues with high sensitivity and specificity. There is currently no evidence that LINC00317 acts as a classical therapeutic target (e.g., receptor, enzyme), nor are there drugs known to interact with or modulate its function directly. Its utility and role are primarily in molecular diagnostics and potentially as a tool for understanding disease mechanisms in oncology.

Other names

LINC00317PRED89C21orf117NCRNA00317