Long intergenic non-protein coding RNA 319 (LINC00319)

Long intergenic non-protein coding RNA 319 (LINC00319) is a long non-coding RNA transcript that does not code for a protein and resides between protein-coding genes in the genome. LINC00319 is upregulated in several human cancers and has been identified as a key modulator of tumor cell proliferation, invasion, self-renewal, metastasis, and apoptosis. Mechanistically, LINC00319 acts primarily by binding and sequestering microRNAs (such as miR-32, miR-200a-3p, miR-199a-5p), thus derepressing oncogenic targets (AURKA, SOX9, TWIST1, FZD4, HMGB3, etc.). In neurological contexts, LINC00319 aggravates neuronal injury by promoting apoptosis through microRNA regulation. Clinically, LINC00319's elevated expression correlates with poor prognosis and aggressive tumor behavior, making it a candidate diagnostic, prognostic marker, and a potential therapeutic target in cancer research. No approved drugs directly target LINC00319 yet, but its inhibition may provide therapeutic benefit in oncology.

Other names

PRED49FLJ38036LOC124900467C21orf125NCRNA00319

Not applicable; mechanistically, LINC00319 acts by sponging microRNAs (e.g., miR-32, miR-200a-3p, miR-199a-5p), modulating downstream targets (e.g., AURKA, SOX9, TWIST1, FZD4, HMGB3). Theoretically, inhibitors (e.g., siRNA, antisense oligonucleotides) may downregulate LINC00319 to suppress malignant phenotypes.