Long intergenic non-protein coding RNA 332 (LINC00332)

Long intergenic non-protein coding RNA 332 (LINC00332) is a human long non-coding RNA (lncRNA) gene located on chromosome 13 (chr13:40181809-40195040, hg38)[7][5]. LINC00332 is transcribed but not translated into protein and is classified within the growing family of lncRNAs, which are transcripts longer than 200 nucleotides with regulatory roles in cellular function and disease[1][11]. In gastric cancer, LINC00332 acts as a tumor suppressor: its expression is significantly downregulated in cancer tissues as compared to normal, and ectopic (experimental) overexpression of LINC00332 reduces markers of epithelial–mesenchymal transition (EMT), inhibits cell proliferation, migration, and invasion, but does not promote apoptosis[2]. LINC00332 may mediate these effects through inverse regulation of matrix metalloproteinase-13 (MMP-13), and may decrease resistance to chemotherapy (cisplatin)[2][4]. It is also implicated in broader lncRNA-mediated regulatory networks, such as ceRNA (competing endogenous RNA) cross-talk, possibly via sponging microRNAs and affecting gene expression relevant to cancer biology[6][8]. Current evidence does not characterize LINC00332 as a classical druggable "target" such as a receptor, enzyme, or transporter, but rather as a regulatory RNA with disease relevance, particularly as a tumor suppressive factor in select cancers[2][4][11].

Other names

NCRNA00332non-protein coding RNA 332