Long intergenic non-protein coding RNA 345 (LINC00345)

LINC00345, or long intergenic non-protein coding RNA 345, is a member of the long intergenic non-coding RNA (lincRNA) family. LincRNAs are RNA transcripts longer than 200 nucleotides that do not overlap with protein-coding genes and typically lack significant protein-coding potential[5]. They are mainly involved in various levels of gene regulation, including acting as molecular sponges for microRNAs, regulating transcription, and modulating the stability and translation of target RNAs[3][5]. LincRNAs, including LINC00345, have been implicated in the regulation of cell proliferation, apoptosis, and cancer-related processes, though specific functions of LINC00345 itself may vary depending on cellular context and disease type[3][5]. Aberrant expression of such lincRNAs is associated with multiple types of cancer, suggesting potential as therapeutic targets or diagnostic biomarkers[3][5]. However, currently no therapeutic drugs or direct modulators are known for LINC00345, and it is not widely considered a classic drug target such as a receptor or enzyme.

Other names

LINC00345