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Long intergenic non-protein coding RNA 358 (LINC00358)
- Target
- LINC00358
- Molecular classification
- Long non-coding RNA (lncRNA), Long intergenic non-coding RNA (lincRNA), Other (non-protein coding gene)
01
Overview
Long intergenic non-protein coding RNA 358 (LINC00358) is a gene encoding a long intergenic non-coding RNA (lincRNA). LINC00358 belongs to the class of lncRNAs, transcripts longer than 200 nucleotides that do not overlap annotated protein-coding genes. LincRNAs are typically involved in modulating gene expression by chromatin remodeling, transcriptional regulation either in cis (acting locally on neighboring genes) or trans (acting distantly), and may participate in broader epigenetic functions. LINC00358's specific biological role and disease associations have not been clearly established in current literature or databases. While the lncRNA class as a whole is actively investigated in cancer and other diseases for their regulatory functions and biomarker potential, most lincRNAs—including LINC00358—remain uncharacterized functionally and are neither established as therapeutic targets nor as clinical biomarkers.
- Other names
- LINC00358Long intergenic non-protein coding RNA 358Ensembl: ENSG00000229578NCBI Gene: 100874143
02
Mechanism of action
Not applicable (no drugs known to interact)
03
Biological functions
Chromatin remodelingTranscription regulationRNA stabilizationRegulation of gene expression (especially neighboring genes, via cis or trans mechanisms)Possible enhancer-associated activityOther functions remain unclear and are often context- or tissue-specific for lincRNAs
04
Disease associations
Other (No clear disease association reported for LINC00358 specifically. General lincRNAs have described roles in cancer progression and prognosis, but this has not been shown for LINC00358 itself)
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