Long intergenic non-protein coding RNA 365 (LINC00365)

Long intergenic non-protein coding RNA 365 (LINC00365) is a long non-coding RNA (lncRNA) that does not code for any protein product and exerts regulatory influence on gene expression. LINC00365 is downregulated in multiple cancers, including gastric, breast, and colorectal cancer, and acts primarily as a tumor suppressor[1][2][4]. It functions partly via the LINC00365-SCGB2A1 axis, inhibiting the NF-κB signaling pathway and promoting apoptosis in cancer cells, and is also implicated in cell cycle regulation by targeting specific mRNAs through miRNA competition[1][2]. In gastric cancer, LINC00365 has been associated with lymph node metastasis and may serve as a diagnostic and prognostic biomarker (AUC >0.8)[1]. In breast cancer, overexpression of LINC00365 reduces cell viability and induces apoptosis[2]. Gene set enrichment indicates a role in MAPK and Wnt/β-catenin pathways, and its dysregulation correlates with clinical outcomes in several cancers[1][2][4]. There are currently no direct drug interactions or therapies that target LINC00365, but it is increasingly recognized as a promising therapeutic and diagnostic target, particularly in oncology[2].

Other names

LINC00365

Modulates gene expression by acting as a competitive endogenous RNA (ceRNA); Inhibits NF-κB signaling pathway via the LINC00365-SCGB2A1 axis; Regulates cell cycle-related genes through miRNA sequestration.