Long intergenic non-protein coding RNA 423 (LINC00423)

Long intergenic non-protein coding RNA 423 (LINC00423) is a long non-coding RNA (lncRNA), approximately 1.3 kb in length, predominantly localized in the cytoplasm. It is characteristically downregulated in retroperitoneal liposarcoma (RLS), and its overexpression suppresses RLS cell growth both in vitro and in vivo[1][3]. LINC00423 exerts its tumor suppressive effects by binding to and destabilizing nuclear factor of activated T-cells 3 (NFATC3), thus negatively regulating the MAPK signaling pathway at the transcriptional level[1][3]. These activities suggest utility as a prognostic biomarker and a candidate therapeutic target for RLS management. There are no reported interactions with approved drugs, and LINC00423 functions as a regulatory non-coding RNA rather than as a classic receptor, enzyme, or transporter[1][3][5].

Other names

linc00423

Not applicable for drugs, but its mechanism includes direct binding to and destabilization of NFATC3, leading to downstream suppression of the MAPK pathway[1][3].