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Long intergenic non-protein coding RNA 424 (LINC00424)
- Target
- LINC00424
- Molecular classification
- Other (long non-coding RNA, lncRNA; not a receptor, enzyme, ion channel, etc.)
01
Overview
Long intergenic non-protein coding RNA 424 (LINC00424) is a long non-coding RNA (lncRNA), meaning it does not encode a protein but instead functions at the RNA level. It has been identified as highly expressed in liver cancer tissues and serum in comparison to normal controls, with elevated levels correlating with advanced tumor stage, lymph node metastasis, and poor prognosis. LINC00424 has potential diagnostic utility, as its expression in serum reflects its status in tumor tissues. However, it is not a canonical therapeutic target like a receptor, enzyme, or transporter, but rather may serve as a biomarker for patient selection or prognosis in cancer. No known drugs directly target LINC00424, and it is not established as a direct drug target in current therapeutics.
- Other names
- LINC00424
02
Biological functions
Regulation of gene expression
03
Disease associations
Cancer (notably hepatocellular carcinoma, based on diagnostic and prognostic associations)
04
Biomarkers
Diagnostic and prognostic biomarker for liver cancer (hepatocellular carcinoma)
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